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Monday, July 27, 2020 | History

7 edition of Fatty Acid and Lipotoxicity in Obesity and Diabetes (Novartis Foundation Symposia) found in the catalog.

Fatty Acid and Lipotoxicity in Obesity and Diabetes (Novartis Foundation Symposia)

by Novartis Foundation

  • 62 Want to read
  • 36 Currently reading

Published by Wiley .
Written in English

    Subjects:
  • Biology, Life Sciences,
  • Clinical & Internal Medicine,
  • Medical,
  • Medical / Nursing,
  • Endocrinology & Metabolism,
  • Medical / Endocrinology & Metabolism

  • The Physical Object
    FormatHardcover
    Number of Pages222
    ID Numbers
    Open LibraryOL10278779M
    ISBN 100470057645
    ISBN 109780470057643

      Keywords Obesity Lipotoxicity Lipolysis Free fatty acid (FFA) Fatty acyl-coenzyme A (FA-CoA) Diacylglycerol (DAG) Ceramide Perilipin Triglyceride Fatty acid translocase (FAT)/CD36 Long-chain fatty acid (LCFA) Plasma membrane-associated fatty acid binding protein (FABPpm) Triacylglycerol Insulin resistance (IR) Mitochondrial dysfunction Lipid droplets Reactive oxygen Cited by:   FATTY ACIDS AND PATHOPHYSIOLOGY. In , understanding of the importance of NEFA changed from physiology to pathophysiology with the description of the glucose-fatty acid cycle by Randle et al. ().The authors suggested that elevated NEFA concentrations were associated with “several abnormalities of carbohydrate metabolism, common to many endocrine and nutritional disorders.”Cited by:

    Lipotoxicity. Lipotoxicity is a common syndrome in which unoxidized long-chain fatty acids (i.e., triacylglycerol) are stored in the body's adipose tissue. 1 Under lipotoxic conditions, these fatty acid chains are stored as lipid cells, or fat, in areas of the body that are not designed to carry such abundant amounts of excess fat. These areas include essential organs such as the heart Author: Samantha Bell.   This animation helps the learner to understand the lipid abnormalities commonly seen in patients with type 2 diabetes. The animation focuses on the major role that elevated plasma free fatty acids.

    Diabetes and apoptosis: lipotoxicity. Obesity is an established risk factor in the pathogenesis of insulin resistance, type 2 diabetes mellitus and cardiovascular disease; all components that are part of the metabolic syndrome. elevated systemic levels of fatty acids are now considered significant contributors towards the Cited by:   Recent evidence points toward decreased oxidative capacity and mitochondrial aberrations as a major contributor to the development of insulin resistance and type 2 diabetes. In this article we will provide an integrative view on the interrelation between decreased oxidative capacity, lipotoxicity, and mitochondrial aberrations in type 2 by:


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Fatty Acid and Lipotoxicity in Obesity and Diabetes (Novartis Foundation Symposia) by Novartis Foundation Download PDF EPUB FB2

Fatty Acids and Lipotoxicity in Obesity and Diabetes will be of interest to anyone working on the causes of obesity and diabetes. From the Back Cover Metabolic diseases such as obesity, diabetes and hypertension are among the most common chronic illnesses and Format: Hardcover.

This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and β cell function and insulin resistance. About this book The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance.

Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic β cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle.

This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and β cell function and insulin resistance.

Fatty Acid and Lipotoxicity in Obesity and Diabetes deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and beta-cell function and insulin resistance.

Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and.

cell function and insulin resistance. Fatty Acids and Lipotoxicity in Obesity and Diabetes will be of interest to anyone working on the causes of obesity and diabetes.

About the Author The Novartis Foundation is an international scientific and educational charity, which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

S DIABETES, VOL. 50, SUPPLEMENT 1, FEBRUARY Lipotoxicity of -Cells in Obesity and in Other Causes of Fatty Acid Spillover Roger H. Unger and Yan-Ting Zhou A recently identified function of leptin is to protect nonadipose tissues from the nonoxidative metabolic products of long-chain fatty acids (FAs) during periodsCited by:   Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover.

R H Unger, Y T Zhou Diabetes Feb50 (suppl 1) S; DOI: /diabetesSCited by: With controversy and ongoing debate surrounding the issue of myocardial fatty acid β-oxidation rates and lipotoxicity in obesity and T2D, a potentially less complicated way to approach this therapeutically is to simply restrict myocardial fatty acid uptake, which should reduce both lipid accumulation and fatty acid β-oxidation rates Cited by:   Lipotoxicity Insulin resistance Type 2 diabetes mellitus Obesity Fatty acids Diacylglycerol Ceramides Cytokines Endoplasmic reticulum stress This is a preview of subscription content, log in to check by: Get this from a library.

Fatty acids and lipotoxicity in obesity and diabetes. [Gregory Bock; Jamie Goode; Novartis Foundation.; Qing hua da xue (Beijing, China);] -- The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance.

Chronic exposure to high. Fatty Acids and Lipotoxicity in Obesity and Diabetes by Novartis Foundation. Fatty Acids and Lipotoxicity in Obesity and Diabetes deals with the molecular aspects of fatty acid action in obesity and insulin resistance.

Fatty Acids and Lipotoxicity in Obesity and Diabetes includes: lipid metabolism adipose tissue biology ß cell function. The economic burden of obesity is also significant.

For instance, the average annual medical costs are times higher for obese patients with the metabolic syndrome compared with those without metabolic syndrome.

12 Obesity accounts for between 2% and 6% of total health care costs in many countries, 6 and in the United States health care expenses for obesity-related conditions were estimated Cited by: FATTY ACIDS AND LIPOTOXICITY IN OBESITY AND DIABETES; Contents; Chair's introduction; Transcriptional control of energy homeostasis through the PGC1 coactivators; Human obesity and insulin resistance: lessons from experiments of nature; Lipid-induced metabolic dysfunction in skeletal muscle; Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes.

A similar book of symposium proceedings, Fatty Acids and Lipotoxicity in Obesity and Diabetes, Spiegelman (John Wiley & Sons, ), appears to have a more narrow focus on lipotoxicity than this book.

Other books discussing obesity and lipotoxicity are difficult to find, pointing to the important role this one may play. Doody's Review ServicePages:   The widespread epidemics of obesity and type 2 diabetes mellitus (T2DM) suggest that both conditions are closely linked.

An increasing body of evidence has shifted our view of adipose tissue from a passive energy depot to a dynamic “endocrine organ” that tightly regulates nutritional balance by means of a complex crosstalk of adipocytes with their by: How to Cite.

Spiegelman, B. () Transcriptional Control of Energy Homeostasis through the PGC1 Coactivators, in Fatty Acids and Lipotoxicity in Obesity and Diabetes: Novartis Foundation Symposium (eds G.

Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: /ch2. The beneficial effect of the Mediterranean diet derived from monounsaturated fatty acids (MUFA), mainly from olive oil.

In this review we document lipotoxicity in obesity Cited by: 6. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Unger RH(1), Zhou YT.

Author information: (1)Department of Internal Medicine, Gifford Laboratories, Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, DallasUSA.

[email protected] by:. Increased plasma free fatty acid levels, especially palmitate, are associated with obesity and lipotoxicity and play a critical role in the development of obesity-induced IR (25). Similarly.Lipotoxicity is a metabolic syndrome that results from the accumulation of lipid intermediates in non-adipose tissue, leading to cellular dysfunction and tissues normally affected include the kidneys, liver, heart and skeletal xicity is believed to have a role in heart failure, obesity, and diabetes, and is estimated to affect approximately 25% of the adult American.Topics covered include lipid metabolism, adipose tissue biology, ß cell function and insulin resistance.

Specific chapters also deal with the molecular genetics and molecular physiology of energy homeostasis. Fatty Acids and Lipotoxicity in Obesity and Diabetes will be of interest to anyone working on the causes of obesity and diabetes.